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Clinical data
Pronunciation/ ˈ s ɪ m v ə s t æ t ɪ n /
Trade namesZocor, other
License dataEU  EMA:  by INN, US   FDA: Simvastatin
Pregnancy categoryAU: D US: X (Contraindicated)
Routes of administrationby mouth
ATC codeC10AA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: P (Pharmacy medicines) when ≤10 mg/day, POM when >10 mg/day., US: ℞-only
Pharmacokinetic data
Protein binding95%
MetabolismHepatic (CYP3A4)
Elimination half-life2 hours for simvastatin and 1.9 hours for simvastatin acid
ExcretionRenal 13%, faecal 60%


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Ng h/ml to 43. +/- 16.It is not known whether simvastatin is excreted into price of simvastatin at walmart milk; however, a small amount of another drug in this class does pass into breast milk. Because statins have the potential for serious adverse reactions in nursing infants, women who require treatment with simvastatin should not breastfeed their infants The risk of myopathy, including rhabdomyolysis, is dose related.

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It should be noted that although 10 mg once daily is an FDA-labeled dosage of simvastatin, this dosage was not evaluated in randomized controlled studies reviewed by the ACC/AHA expert panel."Cardiovascular disease: risk assessment and reduction, including lipid modification at ice.


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7. eme D, Al-Hadad A, Varga T, Szanto E, Sandor K, Rakonczai E. Maximal initial dose of simvastatin causing acute renal failure through rhabdomyolysis: risk factors, pathomechanism and therapy related to a case.Goldman-Cecil Medicine. 26th ed.


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