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Do not give REVATIO to other people, This patient leaflet summarizes the most important information about REVATIO.Dosages exceeding 100 mg once daily are not recommended because of the increased risk of adverse effects and lack of evidence that such doses provide increased efficacy compared with a 100-mg dose. Sildenafil has been shown to remain effective for at least 0.

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Additionally, walk distance and functional class status appeared to be stable in patients taking REVATIO. Without a control group, these data must be interpreted cautiously.The possibility of a hypotensive reaction in patients receiving a selective PDE type 5 inhibitor concomitantly with antihypertensive drug therapy, particularly those receiving multidrug regimens, should be considered, and patients should be informed of this possibility.

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Its effect is more potent on PDE-5 than on other known phosphodiesterases 10-fold for PDE6, greater than 80-fold for PDE1, how much revatio should i take for ed than 700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11 The approximately 4, 00-fold selectivity for PDE-5 versus PDE3 is important because PDE3 is involved in control of cardiac contractility.32 These analogs have not undergone any of the rigorous testing that drugs like sildenafil have passed, and thus have unknown side-effect profiles.

33 Some attempts have been made to ban these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription medicines.

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The area under the plasma concentration-time curve AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific β-adrenergic blocking agents and clearance of the active metabolite was reduced by 31 and 54% respectively; however, the increased active metabolite concentrations are not expected to be clinically important.


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